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ATP hydrolysis is required for relocating cohesin from sites occupied by its Scc2/4 loading complex

Abstract:

Background: The Cohesin complex that holds sister chromatins together until anaphase is comprised of three core subunits: Smc1 and Smc3, two long-rod-shaped proteins with an ABC-like ATPase head (nucleotide-binding domain [NBD]) and a dimerization domain linked by a 50 nm long intramolecular antiparallel coiled-coil, and Scc1, an α-kleisin subunit interconnecting the NBD domains of Smc1 and Smc3. Cohesins stable association with chromosomes is thought to involve entrapment of chromatin fibers...

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Publisher copy:
10.1016/j.cub.2010.12.004

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Journal:
Current Biology More from this journal
Volume:
21
Issue:
1
Pages:
12-24
Publication date:
2011-01-11
DOI:
ISSN:
0960-9822
Language:
English
Pubs id:
pubs:118146
UUID:
uuid:0cf6b168-b75b-41e2-9915-61af0c474f48
Local pid:
pubs:118146
Source identifiers:
118146
Deposit date:
2012-12-19

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