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The distribution of the deleted in colon cancer (DCC) protein in human tissues.

Abstract:

A gene called deleted in colon cancer (DCC) has been identified on a region of chromosome 18, which is deleted in 70% of colorectal cancers. The DCC gene encodes a protein belonging to the immunoglobulin superfamily with similarity to the N-CAM transmembrane proteins and is a putative tumor-suppressor gene. Alternative splicing of transcripts of transmembrane proteins, including N-CAM, is known to occur, resulting in different isoforms of the protein. Using five antibodies against the DCC gen...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
Kocialkowski, S More by this author
Kaklamanis, L More by this author
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Journal:
Cancer research
Volume:
55
Issue:
23
Pages:
5628-5631
Publication date:
1995-12-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:0cf53b44-f3d8-47ca-8bca-a08d5c7d0348
Source identifiers:
486724
Local pid:
pubs:486724

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