Polymorphisms in Tumor Necrosis Factor and Other Cytokines As Risks for Infectious Diseases and the Septic Syndrome.

Journal article

An increasing number of genetic association studies have implicated polymorphisms of cytokine genes as host genetic factors influencing susceptibility to infectious disease, primarily using a candidate gene approach based on knowledge of disease pathogenesis. The application and limitations of association studies are reviewed together with the impact of recent advances in single nucleotide polymorphism mapping on strategic approaches to defining genetic susceptibility loci. It often remains u...

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Authors: Knight, J

• Journal: Current infectious disease reports
• Volume: 3
• Issue: 5
• Pages: 427-439
• Publication date: 2001-10-01
• DOI: 10.1007/s11908-007-1010-3
• EISSN: 1534-3146
• ISSN: 1523-3847
• Language: English