Activation of murine macrophages by Neisseria meningitidis and IFN-gamma in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype.

Journal article

Innate and adaptive immune activation of macrophages (Mphi) by microorganisms and antigen-activated lymphoid cells, respectively, plays an important role in host defense and immunopathology. Antigen-presenting cells express a range of pattern recognition receptors including the class A types I and II scavenger receptors (SR-A) and Toll-like receptors (TLR). Recognition of microbial products by SR-A and TLR controls uptake, killing, altered gene expression, and the adaptive immune response; ho...

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Authors: Mukhopadhyay, S; Peiser, L; Gordon, S

• Publication status: Published
• Journal: Journal of leukocyte biology
• Volume: 76
• Issue: 3
• Pages: 577-584
• Publication date: 2004-09-01
• DOI: 10.1189/jlb.0104014
• EISSN: 1938-3673
• ISSN: 0741-5400
• Language: English
• Keywords: Immunity, Innate; Tumor Necrosis Factor-alpha; Toll-Like Receptors; Macrophages; Up-Regulation; Lipopolysaccharides; Neisseria meningitidis; Membrane Glycoproteins; Phenotype; Mice; Interferon-gamma; Mannose-Binding Lectins; Toll-Like Receptor 4; Mice, Knockout; Inflammation Mediators; Antigens, CD86; Animals; Antigens, CD; Receptors, Cell Surface; Receptors, Immunologic; Scavenger Receptors, Class A; Antigens, CD36; Antigens, CD80; Chemotaxis, Leukocyte; Histocompatibility Antigens Class II; Lectins, C-Type