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Journal article

Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium.

Abstract:

The pulmonary vein is sleeved by myocardium, which is a major source of atrial fibrillation and is involved in congenital sinus venosus defects. Little is known about the cellular origin and mechanism of formation of the pulmonary myocardium. We observed a biphasic process of pulmonary myocardium formation in mice. Firstly, a myocardial cell population forms de novo at the connection of the pulmonary vein and the atrium. Genetic labeling revealed that atrial cells do not contribute to this po...

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Journal:
Circulation research
Volume:
101
Issue:
9
Pages:
902-909
Publication date:
2007-10-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:0cf00581-48c5-4ac4-a634-feccd8c59010
Source identifiers:
482168
Local pid:
pubs:482168

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