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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.

Abstract:

Epidemiological studies suggest that Mediterranean diets rich in resveratrol are associated with reduced risk of coronary artery disease. Resveratrol was also shown to confer vasoprotection in animal models of type 2 diabetes and aging. However, the mechanisms by which resveratrol exerts its antioxidative vasculoprotective effects are not completely understood. Using a nuclear factor-E(2)-related factor-2 (Nrf2)/antioxidant response element-driven luciferase reporter gene assay, we found that...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00260.2010

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
299
Issue:
1
Pages:
H18-H24
Publication date:
2010-07-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:0ceb17a5-9fe2-4fd9-b581-1c9ad39c0b78
Source identifiers:
164509
Local pid:
pubs:164509

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