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Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability.

Abstract:

Signal transduction pathways regulate gene expression in part by modulating the stability of specific mRNAs. For example, the mitogen-activated protein kinase (MAPK) p38 pathway mediates stabilization of tumor necrosis factor alpha (TNF-alpha) mRNA in myeloid cells stimulated with bacterial lipopolysaccharide (LPS). The zinc finger protein tristetraprolin (TTP) is expressed in response to LPS and regulates the stability of TNF-alpha mRNA. We show that stimulation of RAW264.7 mouse macrophages...

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Publication status:
Published

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Authors


Mahtani, KR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Molecular and cellular biology
Volume:
21
Issue:
19
Pages:
6461-6469
Publication date:
2001-10-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:0cea982c-8425-43dc-910e-3cce8bb13973
Source identifiers:
224220
Local pid:
pubs:224220

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