The MEP1A gene, located on human chromosome 6p (mouse chromosome 17) in a susceptibility region for inflammatory bowel disease (IBD), encodes the alpha-subunit of metalloproteinase meprin A, which is expressed in the intestinal epithelium. This study shows a genetic association of MEP1A with IBD in a cohort of ulcerative colitis (UC) patients. There were four single-nucleotide polymorphisms in the coding region (P=0.0012-0.04), and one in the 3'-untranslated region (P=2 x 10(-7)) that display...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record