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MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.

Abstract:

The MEP1A gene, located on human chromosome 6p (mouse chromosome 17) in a susceptibility region for inflammatory bowel disease (IBD), encodes the alpha-subunit of metalloproteinase meprin A, which is expressed in the intestinal epithelium. This study shows a genetic association of MEP1A with IBD in a cohort of ulcerative colitis (UC) patients. There were four single-nucleotide polymorphisms in the coding region (P=0.0012-0.04), and one in the 3'-untranslated region (P=2 x 10(-7)) that display...

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Publication status:
Published

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Publisher copy:
10.1038/mi.2009.3

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Journal:
Mucosal immunology
Volume:
2
Issue:
3
Pages:
220-231
Publication date:
2009-05-05
DOI:
EISSN:
1935-3456
ISSN:
1933-0219
URN:
uuid:0ce4ab29-9228-4950-8a47-a5c09833555a
Source identifiers:
135765
Local pid:
pubs:135765

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