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Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide.

Abstract:

A region near the C-terminus of human acetylcholinesterase (AChE) is weakly homologous with the N-terminus of the Alzheimer's disease amyloid-beta peptide. We report that a 14-amino acid synthetic polypeptide whose sequence corresponds to residues 586-599 of the human synaptic or T form of AChE assembles into amyloid fibrils under physiological conditions. The fibrils have all the classical characteristics of amyloid: they have a diameter of 6-7 nm and bind both Congo red and thioflavin-T. Fu...

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Publication status:
Published

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Publisher copy:
10.1021/bi0260334

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Journal:
Biochemistry
Volume:
41
Issue:
46
Pages:
13539-13547
Publication date:
2002-11-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:0cdf51db-363d-4fb2-b408-2e95d75b8513
Source identifiers:
2894
Local pid:
pubs:2894

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