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Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates.

Abstract:

The malaria parasite Plasmodium falciparum induces a number of novel adhesion properties in the erythrocytes that it infects. One of these properties, the ability of infected erythrocytes to bind uninfected erythrocytes to form rosettes, is associated with severe malaria and may play a direct role in the pathogenesis of disease. Previous work has shown that erythrocytes deficient in complement receptor (CR) 1 (CR1, CD35; C3b/C4b receptor) have greatly reduced rosetting capacity, indicating an...

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Publication status:
Published

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
165
Issue:
11
Pages:
6341-6346
Publication date:
2000-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:0cda9a6d-3b5d-4374-98a0-0eb72029051f
Source identifiers:
27567
Local pid:
pubs:27567

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