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HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.

Abstract:

BACKGROUND: Multiple sclerosis (MS) in the pediatric age group is being increasingly recognized. In adults, complex interactions between genetic and environmental factors contribute to risk and the major genetic component of MS susceptibility localizes to the major histocompatibility complex (human leukocyte antigen [HLA]). Whether HLA alleles predict MS in at-risk children presenting with acquired demyelinating syndromes (ADS) of the CNS is unknown. METHODS: HLA-DRB1 alleles were typed usin...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Neurology More from this journal
Volume:
76
Issue:
9
Pages:
781-786
Publication date:
2011-03-01
DOI:
EISSN:
1526-632X
ISSN:
0028-3878

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