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PH dependence of listeriolysin O aggregation and pore-forming ability

Abstract:

Listeriolysin O (LLO) is the major factor implicated in the escape of Listeria monocytogenes from the phagolysosome. It is the only representative of cholesterol-dependent cytolysins that exhibits pH-dependent activity. Despite intense studies of LLO pH-dependence, this feature of the toxin still remains incompletely explained. Here we used fluorescence and CD spectroscopy to show that the structure of LLO is not detectably affected by pH at room temperature. We observed slightly altered haem...

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Journal:
FEBS Journal
Volume:
279
Issue:
1
Pages:
126-141
Publication date:
2012-01-01
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
Source identifiers:
222481
Language:
English
Keywords:
Pubs id:
pubs:222481
UUID:
uuid:0cd198c1-1692-4a56-85cc-7977af12be8f
Local pid:
pubs:222481
Deposit date:
2012-12-19

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