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The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs.

Abstract:

The protein products of Polycomb group (PcG) and trithorax group (trxG) genes are required for the maintenance of the transcriptionally repressed and active states, respectively, of the homeotic genes. Mutations in PcG genes produce gain-of-function (posterior) homeotic transformations, while mutations in trxG genes produce loss-of-function (anterior) homeotic transformations. Double mutant combinations between a PcG gene and a trxG gene suppress the homeotic transformations seen with either ...

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Publication status:
Published

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Publisher copy:
10.1007/s004380050018
Journal:
Molecular and general genetics : MGG More from this journal
Volume:
261
Issue:
4-5
Pages:
753-761
Publication date:
1999-06-01
DOI:
ISSN:
0026-8925
Language:
English
Keywords:
Pubs id:
pubs:499687
UUID:
uuid:0cce61b9-7d63-4ba0-a55e-de30ec07acb2
Local pid:
pubs:499687
Source identifiers:
499687
Deposit date:
2014-12-20

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