Journal article
T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein.
- Abstract:
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Viral vectored vaccines have been shown to induce both T cell and antibody responses in animals and humans. However, the induction of even higher level T cell responses may be crucial in achieving vaccine efficacy against difficult disease targets, especially in humans. Here we investigate the oligomerization domain of the (Alpha)-chain of C4b-binding protein (C4 bp) as a candidate T cell "molecular adjuvant" when fused to malaria antigens expressed by human adenovirus serotype 5 (AdHu5) vect...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 828.8KB)
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- Publisher copy:
- 10.1371/journal.pone.0044943
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Authors
Funding
Wellcome Trust
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European Malaria Vaccine Development Association
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European Commission
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS One Journal website
- Volume:
- 7
- Issue:
- 9
- Article number:
- e44943
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Source identifiers:
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352439
Item Description
- Language:
- English
- Keywords:
- UUID:
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uuid:0ccc7223-b4bc-46f7-9aeb-d661949ae243
- Local pid:
- pubs:352439
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
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