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T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein.

Abstract:

Viral vectored vaccines have been shown to induce both T cell and antibody responses in animals and humans. However, the induction of even higher level T cell responses may be crucial in achieving vaccine efficacy against difficult disease targets, especially in humans. Here we investigate the oligomerization domain of the (Alpha)-chain of C4b-binding protein (C4 bp) as a candidate T cell "molecular adjuvant" when fused to malaria antigens expressed by human adenovirus serotype 5 (AdHu5) vect...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0044943

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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Hill, AV
Wellcome Trust More from this funder
European Malaria Vaccine Development Association More from this funder
European Commission More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
7
Issue:
9
Pages:
Article: e44943
Chapter number:
ARTN e44943
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:0ccc7223-b4bc-46f7-9aeb-d661949ae243
Source identifiers:
352439
Local pid:
pubs:352439

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