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Journal article

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice.

Abstract:

BACKGROUND: The role of the creatine kinase (CK)/phosphocreatine (PCr) energy buffer and transport system in heart remains unclear. Guanidinoacetate-N-methyltransferase-knockout (GAMT-/-) mice represent a new model of profoundly altered cardiac energetics, showing undetectable levels of PCr and creatine and accumulation of the precursor (phospho-)guanidinoacetate (P-GA). To characterize the role of a substantially impaired CK/PCr system in heart, we studied the cardiac phenotype of wild-type ...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Circulation More from this journal
Volume:
111
Issue:
19
Pages:
2477-2485
Publication date:
2005-05-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Language:
English
Keywords:
Pubs id:
pubs:104218
UUID:
uuid:0cc82b74-45a0-4048-bd52-a0943dc0e29c
Local pid:
pubs:104218
Source identifiers:
104218
Deposit date:
2012-12-19

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