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Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.

Abstract:

BACKGROUND: Chronic inflammation is a characteristic of Alzheimer's disease (AD). An interaction associated with the risk of AD has been reported between polymorphisms in the regulatory regions of the genes for the pro-inflammatory cytokine, interleukin-6 (IL-6, gene: IL6), and the anti-inflammatory cytokine, interleukin-10 (IL-10, gene: IL10). METHODS: We examined this interaction in the Epistasis Project, a collaboration of 7 AD research groups, contributing DNA samples from 1,757 cases of...

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Publication status:
Published

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Publisher copy:
10.1186/1742-2094-6-22

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Journal:
Journal of neuroinflammation More from this journal
Volume:
6
Issue:
1
Pages:
22
Publication date:
2009-01-01
DOI:
EISSN:
1742-2094
ISSN:
1742-2094
Language:
English
Keywords:
Pubs id:
pubs:34850
UUID:
uuid:0cbc26d6-13cb-4d85-ae7f-18bfeee55808
Local pid:
pubs:34850
Source identifiers:
34850
Deposit date:
2012-12-19

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