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Journal article

Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.

Abstract:

Bacteria expressing type III secretion systems (T3SS) have been responsible for the deaths of millions worldwide, acting as key virulence elements in diseases ranging from plague to typhoid fever. The T3SS is composed of a basal body, which traverses both bacterial membranes, and an external needle through which effector proteins are secreted. We report multiple crystal structures of two proteins that sit at the tip of the needle and are essential for virulence: IpaD from Shigella flexneri an...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m607945200

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
282
Issue:
6
Pages:
4035-4044
Publication date:
2007-02-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
18279
Language:
English
Keywords:
Pubs id:
pubs:18279
UUID:
uuid:0cbb19e6-73f0-4583-8259-360b7fbdb128
Local pid:
pubs:18279
Deposit date:
2012-12-19

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