Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1

Journal article

Organic cation transporter 1 (OCT1), located in the sinusoidal membrane of hepatocytes, mediates hepatic uptake and elimination of weak bases and cationic compounds like metformin, morphine or fenoterol. With over 200 known substrates, OCT1 exhibits broad polyspecificity. Despite its discovery over 30 years ago, the molecular mechanisms enabling this polyspecific transport are not completely understood. Recent cryo-electron microscopy (cryo-EM) structures provide snapshots of OCT1 in multiple...

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Authors: Parker, JL; Kato, T; Kuteyi, G; Sitsel, O; Newstead, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature Structural & Molecular Biology
• Volume: 30
• Issue: 11
• Pages: 1786-1793
• Publication date: 2023-07-23
• DOI: 10.1038/s41594-023-01039-y
• EISSN: 1545-9985
• ISSN: 1545-9993
• Language: English
• Keywords: Kidney; Organic anion transporter 1; Organic cation transport proteins; Intracellular; Nephron; Renal function; Biology; Pharmacology; Biochemistry; Endocrinology; Metabolite; Probenecid; Transporter; Organic anion; Nephrotoxicity; Chemistry; Enzyme; Allosteric regulation