Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels.

Journal article

Calcium signaling is essential for the differentiation of many cell types, including skeletal muscle cells, but its mechanisms remain elusive. Here we demonstrate a crucial role for nicotinic acid adenine dinucleotide phosphate (NAADP) signaling in skeletal muscle differentiation. Although the inositol trisphosphate pathway may have a partial role to play in this process, the ryanodine signaling cascade is not involved. In both skeletal muscle precursors and C2C12, cells interfering with NAAD...

Expand abstract

Authors: Aley, P; Mikolajczyk, A; Munz, B; Churchill, G; Galione, A

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 107
• Issue: 46
• Pages: 19927-19932
• Publication date: 2010-11-01
• DOI: 10.1073/pnas.1007381107
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Muscle, Skeletal; Down-Regulation; Ryanodine; Calcium; Acids; Endoplasmic Reticulum; Signal Transduction; Cells, Cultured; Inositol 1,4,5-Trisphosphate; Mice; Animals; NADP; Calcium Channels; Second Messenger Systems; Cell Differentiation