Beijing genotype of Mycobacterium tuberculosis is significantly associated with high-level fluoroquinolone resistance in Vietnam.

Journal article

Consecutive fluoroquinolone (FQ)-resistant isolates (n = 109) identified at the Pham Ngoc Thach Hospital for Tuberculosis, Ho Chi Minh City, Vietnam, were sequenced in the quinolone resistance-determining regions of the gyrA and gyrB genes and typed by large sequence polymorphism typing and spoligotyping to identify the Beijing genotype of Mycobacterium tuberculosis. Beijing genotype prevalence was compared with 109 consecutive isolates from newly presenting patients with pulmonary tuberculos...

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Authors: Duong, D; Nguyen, T; Nguyen, T; Dai, V; Dang, T

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 53
• Issue: 11
• Pages: 4835-4839
• Publication date: 2009-11-01
• DOI: 10.1128/aac.00541-09
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Mutation; Bacterial Typing Techniques; Drug Resistance, Bacterial; Mycobacterium tuberculosis; Fluoroquinolones; DNA Gyrase; Genotype; Anti-Infective Agents; Microbial Sensitivity Tests