- Abstract:
-
Many enzymes that repair or modify bases in double-stranded DNA gain access to their substrates by base flipping. Although crystal structures provide stunning snap shots, biochemical approaches addressing the dynamics have proven difficult, particularly in complicated multi-step reactions. Here, we use protein-DNA crosslinking and potassium permanganate reactivity to explore the base-flipping step in tN5 transposition. We present a model to suggest that base flipping is driven by a combinatio...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 639.3KB)
-
- Publisher copy:
- 10.1093/nar/gkm186
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 35
- Issue:
- 8
- Pages:
- 2584-2595
- Publication date:
- 2007-04-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
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0305-1048
- URN:
-
uuid:0cae0044-30d3-498c-94b9-d38efc28e5b2
- Local pid:
- ora:3020
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Julien Bischerour and Ronald Chalmers*
- Copyright date:
- 2007
- Notes:
- Citation: Bischerour, J. & Chalmers, R. (2007). 'Base-flipping dynamics in a DNA hairpin processing reaction', Nucleic Acids Research, 35(8), 2584-2595. [Available at http://nar.oxfordjournals.org/]. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Base-flipping dynamics in a DNA hairpin processing reaction
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