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Changes in the Vα7.2+ CD161++ MAIT cell compartment in early pregnancy are associated with preterm birth in HIV-positive women

Abstract:

Problem: Human immunodeficiency virus (HIV) infection is associated with an increased risk of adverse pregnancy outcomes, including preterm birth (PTB), despite viral suppression with antiretroviral therapy. Mucosal‐associated invariant T (MAIT) cells are an immune cell subset involved in antimicrobial immunity at mucosal surfaces. MAIT cells have been found at the maternal‐foetal interface, and MAIT cells are typically depleted early in HIV infection. We aimed to inv...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/aji.13240

Authors


More from this funder
Name:
Wellcome Trust
Grant:
105605/Z/14/Z
More from this funder
Name:
Oxfordshire Health Service Research Comm
Grant:
1092
Publisher:
Wiley
Journal:
American Journal of Reproductive Immunology More from this journal
Volume:
83
Issue:
6
Article number:
e13240
Publication date:
2020-04-07
Acceptance date:
2020-03-06
DOI:
EISSN:
1600-0897
ISSN:
1046-7408
Language:
English
Keywords:
Pubs id:
1097490
Local pid:
pubs:1097490
Deposit date:
2020-03-30

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