Journal article icon

Journal article

Toll-like receptor activation during cutaneous allergen sensitization blocks development of asthma through IFN-gamma-dependent mechanisms.

Abstract:

Toll-like receptors (TLRs) are pattern-recognition receptors that have a pivotal role as primary sensors of microbial products and as initiators of innate and adaptive immune responses. We investigated the role of TLR2, TLR3, and TLR4 activation during cutaneous allergen sensitization in the modulation of allergic asthma. The results show that dermal exposure to TLR4 ligand lipopolysaccharide (LPS) or TLR2 ligand Pam3Cys suppresses asthmatic responses by reducing airway hyperreactivity, mucus...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/jid.2012.356

Authors


Journal:
Journal of investigative dermatology More from this journal
Volume:
133
Issue:
4
Pages:
964-972
Publication date:
2013-04-01
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
Language:
English
Keywords:
Pubs id:
pubs:387512
UUID:
uuid:0ca34b36-6633-49bd-b31c-39f69c199c08
Local pid:
pubs:387512
Source identifiers:
387512
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP