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Journal article

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo

Abstract:

The Notch ligands Dll1 and Dll3 are coexpressed in the presomitic mesoderm of mouse embryos. Despite their coexpression, mutations in Dll1 and Dll3 cause strikingly different defects. To determine if there is any functional equivalence, we replaced Dll1 with Dll3 in mice. Dll3 does not compensate for Dll1; DLL1 activates Notch in Drosophila wing discs, but DLL3 does not. We do not observe evidence for antagonism between DLL1 and DLL3, or repression of Notch activity in mice or Drosophila. In ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1083/jcb.200702009

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Publisher:
Rockefeller University Press Publisher's website
Journal:
The Journal of Cell Biology Journal website
Volume:
178
Issue:
3
Pages:
465-476
Publication date:
2007-01-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:0ca1e02d-18f0-448d-b56b-1c227233c813
Source identifiers:
573456
Local pid:
pubs:573456

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