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Enzymatic removal of chondroitin sulphates abolishes the age-related axon order in the optic tract of mouse embryos.

Abstract:

Retinal axons undergo an age-related reorganization at the junction of the chiasm and the optic tract. We have investigated the effects of removal of chondroitin sulphate on this order change in mouse embryos aged embryonic day 14, when most axons are growing in the optic tract. Enzymatic removal of chondroitin sulphate but not keratan sulphate in brain slice preparations of the retinofugal pathway abolished the accumulation of phalloidin-positive growth cones in the subpial region of the opt...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
European journal of neuroscience More from this journal
Volume:
17
Issue:
9
Pages:
1755-1767
Publication date:
2003-05-01
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Language:
English
Keywords:
Pubs id:
pubs:95105
UUID:
uuid:0c9fe096-f9bb-4041-8108-6a9d11df4c95
Local pid:
pubs:95105
Source identifiers:
95105
Deposit date:
2012-12-19

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