Enzymatic removal of chondroitin sulphates abolishes the age-related axon order in the optic tract of mouse embryos.

Journal article

Retinal axons undergo an age-related reorganization at the junction of the chiasm and the optic tract. We have investigated the effects of removal of chondroitin sulphate on this order change in mouse embryos aged embryonic day 14, when most axons are growing in the optic tract. Enzymatic removal of chondroitin sulphate but not keratan sulphate in brain slice preparations of the retinofugal pathway abolished the accumulation of phalloidin-positive growth cones in the subpial region of the opt...

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Authors: Leung, K; Taylor, J; Chan, S

• Journal: European journal of neuroscience
• Volume: 17
• Issue: 9
• Pages: 1755-1767
• Publication date: 2003-05-01
• DOI: 10.1046/j.1460-9568.2003.02605.x
• EISSN: 1460-9568
• ISSN: 0953-816X
• Language: English
• Keywords: Pregnancy; Mice; Animals; Aging; Female; Mice, Inbred C57BL; Chondroitin ABC Lyase; Neural Pathways; Axons; Embryo, Mammalian; Chondroitin Sulfates; Visual Pathways