Journal article icon

Journal article

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.

Abstract:

BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive. METHODS: To elucidate molecular systems associated with AD, we developed a large scale gene expression dataset from 1053 postmortem brain samples across 19 cortical regions of 125 individuals with a severity spectrum of de...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1186/s13073-016-0355-3

Authors


More from this funder
Name:
NIH/National Institute on Aging
Grant:
R01AG046170
Publisher:
BioMed Central
Journal:
Genome Med More from this journal
Issue:
1
Publication date:
2016-11-01
Acceptance date:
2016-09-14
DOI:
ISSN:
1756-994X
Language:
English
Keywords:
Pubs id:
pubs:656895
UUID:
uuid:0c8abeb5-c1ea-48a8-b150-f2ecbe710491
Local pid:
pubs:656895
Source identifiers:
656895
Deposit date:
2016-11-12

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP