Journal article
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.
- Abstract:
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BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical and genomic studies, the molecular basis of AD development and progression remains elusive. METHODS: To elucidate molecular systems associated with AD, we developed a large scale gene expression dataset from 1053 postmortem brain samples across 19 cortical regions of 125 individuals with a severity spectrum of de...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Funding
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Genome Med Journal website
- Issue:
- 1
- Publication date:
- 2016-11-01
- Acceptance date:
- 2016-09-14
- DOI:
- ISSN:
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1756-994X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:656895
- UUID:
-
uuid:0c8abeb5-c1ea-48a8-b150-f2ecbe710491
- Local pid:
- pubs:656895
- Source identifiers:
-
656895
- Deposit date:
- 2016-11-12
Terms of use
- Copyright holder:
- Wang et al
- Copyright date:
- 2016
- Notes:
-
Copyright 2016 The Author(s).
This is the publisher's version of the article. The final version is available online from BioMed Central at: https://doi.org/10.1186/s13073-016-0355-3
- Licence:
- CC Attribution (CC BY)
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