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High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo

Abstract:

Background. Parvovirus 4 (PARV4) is a recently identified human virus that has been found in livers of patients infected with hepatitis C virus (HCV) and in bone marrow of individuals infected with human immunodeficiency virus (HIV). T cells are important in controlling viruses but may also contribute to disease pathogenesis. The interaction of PARV4 with the cellular immune system has not been described. Consequently, we investigated whether T cell responses to PARV4 could be detected in ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/infdis/jir036

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
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Institution:
University of Edinburgh
Department:
Centre for Infectious Diseases
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Institution:
University of Edinburgh
Department:
Centre for Infectious Diseases
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Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of
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Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of
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Medical Research Council, UK More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
203
Issue:
10
Pages:
1378-1387
Publication date:
2011
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:0c85ea7b-8927-41e2-9cde-c5a7d0fd74a3
Local pid:
ora:6443
Language:
English
Keywords:
Subjects:

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