Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.

Journal article

The issue of which melanocortin receptor (MC-R) is responsible for the anti-inflammatory effects of melanocortin peptides is still a matter of debate. Here we have addressed this aspect using a dual pharmacological and genetic approach, taking advantage of the recent characterization of more selective agonists/antagonists at MC1 and MC3-R as well as of the existence of a naturally defective MC1-R mouse strain, the recessive yellow (e/e) mouse. RT-PCR and ultrastructural analyses showed the pr...

Expand abstract

Authors: Getting, S; Christian, H; Lam, C; Gavins, F; Flower, R

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 170
• Issue: 6
• Pages: 3323-3330
• Publication date: 2003-03-01
• DOI: 10.4049/jimmunol.170.6.3323
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Peritonitis; Uric Acid; Receptors, Corticotropin; Cells, Cultured; Cytokines; Animals; Genes, Recessive; Receptor, Melanocortin, Type 3; Anti-Inflammatory Agents, Non-Steroidal; Melanocyte-Stimulating Hormones; Crystallization; Male; Receptors, Melanocortin; gamma-MSH; Macrophages, Peritoneal; Mice, Mutant Strains; Cell Movement; Injections, Intraperitoneal; Pigmentation; Mice; Mice, Inbred C57BL