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Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.

Abstract:

The issue of which melanocortin receptor (MC-R) is responsible for the anti-inflammatory effects of melanocortin peptides is still a matter of debate. Here we have addressed this aspect using a dual pharmacological and genetic approach, taking advantage of the recent characterization of more selective agonists/antagonists at MC1 and MC3-R as well as of the existence of a naturally defective MC1-R mouse strain, the recessive yellow (e/e) mouse. RT-PCR and ultrastructural analyses showed the pr...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.170.6.3323

Authors


Getting, SJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Gavins, FN More by this author
Flower, RJ More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
170
Issue:
6
Pages:
3323-3330
Publication date:
2003-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:0c85c782-b1a7-4a16-856e-3d48da357608
Source identifiers:
114587
Local pid:
pubs:114587

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