Journal article icon

Journal article

Regulation of calcium in pancreatic α- and β-cells in health and disease

Abstract:

The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca 2+-influx via voltage-gated Ca 2+-channels, elevation of [Ca 2+] i and initiation of Ca 2+-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca 2+...

Expand abstract

Actions


Access Document


Publisher copy:
10.1016/j.ceca.2011.11.006

Authors


Journal:
Cell Calcium
Volume:
51
Issue:
3-4
Pages:
300-308
Publication date:
2012-03-01
DOI:
EISSN:
1532-1991
ISSN:
0143-4160
Source identifiers:
321378
Language:
English
Keywords:
Pubs id:
pubs:321378
UUID:
uuid:0c849c5f-22ee-441f-b628-ae5e9bc4712a
Local pid:
pubs:321378
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP