Journal article
Regulation of calcium in pancreatic α- and β-cells in health and disease
- Abstract:
-
The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca 2+-influx via voltage-gated Ca 2+-channels, elevation of [Ca 2+] i and initiation of Ca 2+-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca 2+...
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- Publisher copy:
- 10.1016/j.ceca.2011.11.006
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Bibliographic Details
- Journal:
- Cell Calcium
- Volume:
- 51
- Issue:
- 3-4
- Pages:
- 300-308
- Publication date:
- 2012-03-01
- DOI:
- EISSN:
-
1532-1991
- ISSN:
-
0143-4160
- Source identifiers:
-
321378
Item Description
Terms of use
- Copyright date:
- 2012
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