Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus.

Borrow, P; Lewicki, H; Wei, X; Horwitz, MS; Peffer, N; Meyers, H; Nelson, JA; Gairin, JE; Hahn, BH; Oldstone, MB; Shaw, GM

Abstract:

The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV-1 infection, but definitive evidence that it is of importance in virus containment has been lacking. Here we show that in a patient whose early CTL response was focused on a highly immunodominant epitope in gp 160, there was rapid elimination of the transmitted virus strain and selection for a virus population bearing amino acid changes at a single residue within th...

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APA Style

Borrow, P., Lewicki, H., Wei, X., Horwitz, M. S., Peffer, N., Meyers, H., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B., & Shaw, G. M. (1997). Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nature Medicine, 3(2), 205–211.

MLA Style

Borrow, P., et al. “Antiviral Pressure Exerted by HIV-1-Specific Cytotoxic T Lymphocytes (CTLs) during Primary Infection Demonstrated by Rapid Selection of CTL Escape Virus.” Nature Medicine, vol. 3, no. 2, 1997, pp. 205–11.

Chicago Style

Borrow, P, H Lewicki, X Wei, MS Horwitz, N Peffer, H Meyers, JA Nelson, et al. 1997. “Antiviral Pressure Exerted by HIV-1-Specific Cytotoxic T Lymphocytes (CTLs) during Primary Infection Demonstrated by Rapid Selection of CTL Escape Virus.” Nature Medicine 3 (2): 205–11.
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