Journal article
Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus.
- Abstract:
-
The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV-1 infection, but definitive evidence that it is of importance in virus containment has been lacking. Here we show that in a patient whose early CTL response was focused on a highly immunodominant epitope in gp 160, there was rapid elimination of the transmitted virus strain and selection for a virus population bearing amino acid changes at a single residue within th...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nm0297-205
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Authors
Bibliographic Details
- Journal:
- Nature medicine
- Volume:
- 3
- Issue:
- 2
- Pages:
- 205-211
- Publication date:
- 1997-02-01
- DOI:
- EISSN:
-
1546-170X
- ISSN:
-
1078-8956
- Source identifiers:
-
36011
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:36011
- UUID:
-
uuid:0c801680-9f44-47c4-8d27-f8fbf95fdf20
- Local pid:
- pubs:36011
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1997
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