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Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus.

Abstract:

The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV-1 infection, but definitive evidence that it is of importance in virus containment has been lacking. Here we show that in a patient whose early CTL response was focused on a highly immunodominant epitope in gp 160, there was rapid elimination of the transmitted virus strain and selection for a virus population bearing amino acid changes at a single residue within th...

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Publication status:
Published

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Publisher copy:
10.1038/nm0297-205

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Nature medicine
Volume:
3
Issue:
2
Pages:
205-211
Publication date:
1997-02-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:0c801680-9f44-47c4-8d27-f8fbf95fdf20
Source identifiers:
36011
Local pid:
pubs:36011

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