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Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke.

Abstract:

Reperfusion therapy with tissue plasminogen activator (tPA) is a rational therapy for acute ischemic stroke. Properly titrated use of tPA improves clinical outcomes. However, there is also an associated risk of hemorrhagic transformation after tPA therapy. Emerging data now suggest that some of these potentially neurotoxic side effects of tPA may be due to its signaling actions in the neurovascular unit. Besides its intended role in clot lysis, tPA is also an extracellular protease and signal...

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Publication status:
Published

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Volume:
35
Issue:
11 Suppl 1
Pages:
2726-2730
Publication date:
2004-11-05
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
URN:
uuid:0c731d05-c537-4eea-910d-611cc70667cf
Source identifiers:
79263
Local pid:
pubs:79263

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