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The role of flexibility and conformational selection in the binding promiscuity of PDZ domains

Abstract:

In molecular recognition, it is often the case that ligand binding is coupled to conformational change in one or both of the binding partners. Two hypotheses describe the limiting cases involved; the first is the induced fit and the second is the conformational selection model. The conformational selection model requires that the protein adopts conformations that are similar to the ligand-bound conformation in the absence of ligand, whilst the induced-fit model predicts that the ligand-bound ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1002749

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Computational Biology More from this journal
Volume:
8
Issue:
11
Pages:
ARTN e1002749
Publication date:
2012-11-01
Acceptance date:
2012-09-02
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Language:
English
Keywords:
Pubs id:
pubs:358319
UUID:
uuid:0c6f970d-a0c3-46d9-8b27-bbeb10a07efe
Local pid:
pubs:358319
Source identifiers:
358319
Deposit date:
2013-11-16

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