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Agonists of TRAIL death receptors induce myeloma cell apoptosis that is not prevented by cells of the bone marrow microenvironment.

Abstract:

The growth and survival of myeloma cells is critically regulated by cells of the bone marrow microenvironment, including osteoblasts. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of myeloma cell apoptosis, however, this antimyeloma activity is inhibited by osteoprotegerin (OPG) released from osteoblasts. Therefore, we hypothesized that specific agonists of TRAIL death receptors would not be inhibited by OPG released from osteoblasts and thus may represe...

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Publication status:
Published

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Publisher copy:
10.1038/sj.leu.2404518

Authors


Locklin, RM More by this author
Croucher, PI More by this author
Russell, RG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Leukemia
Volume:
21
Issue:
4
Pages:
805-812
Publication date:
2007-04-05
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
URN:
uuid:0c6782fa-a809-4adf-b5dc-88c767a70a52
Source identifiers:
16398
Local pid:
pubs:16398

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