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Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.

Abstract:

Because of its mechanical function, skeletal muscle is heavily influenced by the composition of its extracellular matrix (ECM). Fibrosis generated by chronic damage, such as occurs in muscular dystrophies, is thus particularly disastrous in this tissue. Here, we examined the interrelationship between the muscle satellite cell and the production of collagen type I, a major component of fibrotic ECM, by using both C2C12, a satellite cell-derived cell line, and primary muscle satellite cells. In...

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Publication status:
Published

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Publisher copy:
10.1152/ajpcell.00061.2007

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
American journal of physiology. Cell physiology More from this journal
Volume:
293
Issue:
2
Pages:
C661-C669
Publication date:
2007-08-01
DOI:
EISSN:
1522-1563
ISSN:
0363-6143

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