Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.

Journal article

Because of its mechanical function, skeletal muscle is heavily influenced by the composition of its extracellular matrix (ECM). Fibrosis generated by chronic damage, such as occurs in muscular dystrophies, is thus particularly disastrous in this tissue. Here, we examined the interrelationship between the muscle satellite cell and the production of collagen type I, a major component of fibrotic ECM, by using both C2C12, a satellite cell-derived cell line, and primary muscle satellite cells. In...

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Authors: Alexakis, C; Partridge, T; Bou-Gharios, G

• Publication status: Published
• Journal: American journal of physiology. Cell physiology
• Volume: 293
• Issue: 2
• Pages: C661-C669
• Publication date: 2007-08-01
• DOI: 10.1152/ajpcell.00061.2007
• EISSN: 1522-1563
• ISSN: 0363-6143
• Language: English
• Keywords: Fibrosis; Collagen Type III; PAX7 Transcription Factor; Myogenin; Disease Models, Animal; MyoD Protein; RNA, Messenger; Aging; Mice; Cell Differentiation; Antigens, CD34; Muscular Dystrophy, Animal; Dose-Response Relationship, Drug; Animals; Collagen Type I; Phenotype; Mice, Inbred mdx; Satellite Cells, Skeletal Muscle; Mice, Inbred C57BL; Up-Regulation; Cell Line; Muscular Dystrophy, Duchenne; Cell Proliferation; Muscle, Skeletal