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Guiding the folding pathway of DNA origami

Abstract:

DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short ‘staple’ strands1,2,3,4. Its guiding design principle is that the target structure is the single most stable configuration5. The folding transition is cooperative4,6,7 and, as in the case of proteins, is governed by information encoded in the polymer sequence8,9,10,11. A typical origami folds primarily into the desired shape, but misfolded structu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature14860

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
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Name:
European Research Council
Grant:
VERIWARE
More from this funder
Name:
Human Frontier Science Program
Grant:
RGP0030/2013
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
EP/G037930/1
EP/P504287/1
Publisher:
Nature Publishing Group
Journal:
Nature More from this journal
Volume:
525
Issue:
7567
Pages:
82–86
Publication date:
2015-08-19
Acceptance date:
2015-06-16
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
UUID:
uuid:0c653a04-11ed-4123-9b9b-188bedadbc52
Deposit date:
2015-11-05

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