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Virus-like particles as vaccine adjuvants.

Abstract:

Virus-like particles (VLPs) consist of one or more viral coat proteins that assemble into particles. They can be taken up by antigen presenting cells (APC), peptides derived from them are presented on MHC class I molecules at the cell surface, and thereby prime a CD8+ T cell response, either against the particle-forming protein itself (such as Hepatitis B surface antigen) or additional peptide sequences that are produced as fusions with the particle-forming protein. This article describes the...

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Publication status:
Published

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Publisher copy:
10.1385/mb:19:2:169

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Molecular biotechnology
Volume:
19
Issue:
2
Pages:
169-177
Publication date:
2001-10-05
DOI:
EISSN:
1559-0305
ISSN:
1073-6085
URN:
uuid:0c622d15-1c0c-4d54-897b-1bade22f76f1
Source identifiers:
32003
Local pid:
pubs:32003

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