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Journal article

O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer

Abstract:

ST6GalNAc-I, the sialyltransferase responsible for sialyl-Tn (sTn) synthesis, has been previously reported to be positively associated with cancer aggressiveness. Here we describe a novel sTn-dependent mechanism for chemotherapeutic resistance. We show that sTn protects cancer cells against chemotherapeutic-induced cell death by decreasing the interaction of cell surface glycan receptors with galectin-3 and increasing its intracellular accumulation. Moreover, exogenously added galectin-3 pote...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.13192

Authors


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Name:
GastricGlycoExplorer
Funding agency for:
Chammas, R
Grant:
316929
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Name:
FEDER
Funding agency for:
Chammas, R
Grant:
316929
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Name:
IPATIMUP
Funding agency for:
Chammas, R
Grant:
316929
More from this funder
Name:
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Funding agency for:
Dias Baruffi, M
Grant:
467646/2014-7
More from this funder
Name:
Núcleo de Apoio à Pesquisa em Doenças Inflamatórias
Grant:
11.1.21625.01.0
Publisher:
Impact Journals
Journal:
Oncotarget More from this journal
Volume:
7
Issue:
50
Pages:
83570-53587
Publication date:
2016-11-08
Acceptance date:
2016-10-21
DOI:
ISSN:
1949-2553
Language:
English
Keywords:
Pubs id:
pubs:661758
UUID:
uuid:0c611de1-b329-456d-9aac-f4312db1c736
Local pid:
pubs:661758
Source identifiers:
661758
Deposit date:
2017-06-14

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