Journal article
O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer
- Abstract:
-
ST6GalNAc-I, the sialyltransferase responsible for sialyl-Tn (sTn) synthesis, has been previously reported to be positively associated with cancer aggressiveness. Here we describe a novel sTn-dependent mechanism for chemotherapeutic resistance. We show that sTn protects cancer cells against chemotherapeutic-induced cell death by decreasing the interaction of cell surface glycan receptors with galectin-3 and increasing its intracellular accumulation. Moreover, exogenously added galectin-3 pote...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Conselho Nacional de Desenvolvimento Científico e Tecnológico
More from this funder
Funding agency for:
Dias Baruffi, M
Grant:
467646/2014-7
Bibliographic Details
- Publisher:
- Impact Journals Publisher's website
- Journal:
- Oncotarget Journal website
- Volume:
- 7
- Issue:
- 50
- Pages:
- 83570-53587
- Publication date:
- 2016-11-08
- Acceptance date:
- 2016-10-21
- DOI:
- ISSN:
-
1949-2553
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:661758
- UUID:
-
uuid:0c611de1-b329-456d-9aac-f4312db1c736
- Local pid:
- pubs:661758
- Source identifiers:
-
661758
- Deposit date:
- 2017-06-14
Terms of use
- Copyright holder:
- Santos, et al 2017
- Copyright date:
- 2016
- Notes:
- This is an open access article published under a creative commons license, see: https://creativecommons.org/licenses/by/3.0/
- Licence:
- CC Attribution (CC BY)
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