Development of a refined tenocyte expansion culture technique for tendon tissue engineering.

Journal article

The aim of this study was to efficiently expand less differentiated tenocytes with minimum use of fetal bovine serum (FBS) for tenocyte-based tendon tissue engineering. To achieve this goal, human tenocytes were cultured in different concentrations of FBS and combinations of growth factors PDGFBB , IGF-1 and bFGF. A number of growth factors were selected that could support tenocyte expansion at reduced differentiated state with minimum FBS usage. Results showed that the expansion of the tenoc...

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Authors: Qiu, Y; Wang, X; Zhang, Y; Carr, A; Zhu, L

• Publication status: Published
• Journal: Journal of tissue engineering and regenerative medicine
• Volume: 8
• Issue: 12
• Pages: 955-962
• Publication date: 2014-12-01
• DOI: 10.1002/term.1597
• EISSN: 1932-7005
• ISSN: 1932-6254
• Language: English
• Keywords: tissue engineering; differentiation; tenocyte; growth factors; fetal bovine serum; expansion