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Journal article

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.

Abstract:

Genome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1B, also known as MT(2)) increase type 2 diabetes (T2D) risk(1,2). Although the strongest association signal was highly significant (P < 1 × 10(-20)), its contribution to T2D risk was modest (odds ratio (OR) of ∼1.10-1.15)(1-3). We performed large-scale exon resequencing in 7,632 Europeans, including 2,186 individuals with T2D, and identified 40 nonsynonymous variants, includ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.1053

Authors


Bonnefond, A More by this author
Clément, N More by this author
Fawcett, K More by this author
Vaillant, E More by this author
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Journal:
Nature genetics
Volume:
44
Issue:
3
Pages:
297-301
Publication date:
2012-03-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:0c5ec836-b1f5-4589-850f-0948dab99529
Source identifiers:
313513
Local pid:
pubs:313513

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