- Abstract:
-
Genome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1B, also known as MT(2)) increase type 2 diabetes (T2D) risk(1,2). Although the strongest association signal was highly significant (P < 1 × 10(-20)), its contribution to T2D risk was modest (odds ratio (OR) of ∼1.10-1.15)(1-3). We performed large-scale exon resequencing in 7,632 Europeans, including 2,186 individuals with T2D, and identified 40 nonsynonymous variants, includ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng.1053
-
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- Journal:
- Nature genetics
- Volume:
- 44
- Issue:
- 3
- Pages:
- 297-301
- Publication date:
- 2012-03-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:0c5ec836-b1f5-4589-850f-0948dab99529
- Source identifiers:
-
313513
- Local pid:
- pubs:313513
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.
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