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Journal article

Production, crystallization, and preliminary X-ray analysis of the human MHC class Ib molecule HLA-E.

Abstract:

HLA-E is the first human class Ib major histocompatibility complex molecule to be crystallized. HLA-E is highly conserved and almost nonpolymorphic, and has recently been shown to be the first specialized ligand for natural killer cell receptors. In functional studies, HLA-E is unlike the class Ia MHC molecules in having tightly restricted peptide binding specificity. HLA-E binds a limited set of almost identical leader sequence peptides derived from class Ia molecules and presents these at t...

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Publication status:
Published

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Publisher copy:
10.1002/pro.5560070525

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
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Journal:
Protein science : a publication of the Protein Society
Volume:
7
Issue:
5
Pages:
1264-1266
Publication date:
1998-05-05
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
URN:
uuid:0c5bcdc6-11bf-42e2-9ec9-613b82df25cc
Source identifiers:
9665
Local pid:
pubs:9665

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