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Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice

Abstract:

Background In the current study, we have investigated whether low density lipoprotein receptor knockout mice (LDLR-KO), moderate oxidative stress model and cholesteremia burden display gastroparesis and if so whether nitrergic system is involved in this setting. In addition, we have investigated if sepiapterin (SEP) supplementation attenuated impaired nitrergic system and delayed gastric emptying. Methods Gastric emptying and nitrergic relaxation were measured in overnight fasting mice. nNOSα...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
Neurogastroenterology and Motility
Volume:
23
Issue:
8
Publication date:
2011-08-05
DOI:
EISSN:
1365-2982
ISSN:
1350-1925
URN:
uuid:0c5b3629-7788-4ae2-a3ac-e3110aff2778
Source identifiers:
170299
Local pid:
pubs:170299

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