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Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1.

Abstract:

Endotoxin-related acute kidney injury has been shown to profoundly induce nitric oxide (NO), which activates sympathetic and renin-angiotensin system, resulting in renal vasoconstriction. While vascular muscle cells are known to upregulate inducible NO synthase (iNOS), less is known about the endothelium as a source of NO during endotoxemia. Studies were, therefore, undertaken both in vitro in mouse microvascular endothelial cells and in vivo in transgenic mice with overexpression of endothel...

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Publication status:
Published

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Publisher copy:
10.1152/ajprenal.00538.2007

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Journal:
American journal of physiology. Renal physiology
Volume:
294
Issue:
3
Pages:
F571-F576
Publication date:
2008-03-01
DOI:
EISSN:
1522-1466
ISSN:
1931-857X
Source identifiers:
105234

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