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Optimizing collimator margins for isotoxically dose-escalated conformal radiation therapy of non-small cell lung cancer.

Abstract:

PURPOSE: Isotoxic dose escalation schedules such as IDEAL-CRT [isotoxic dose escalation and acceleration in lung cancer chemoradiation therapy] (ISRCTN12155469) individualize doses prescribed to lung tumors, generating a fixed modeled risk of radiation pneumonitis. Because the beam penumbra is broadened in lung, the choice of collimator margin is an important element of the optimization of isotoxic conformal radiation therapy for lung cancer. METHODS AND MATERIALS: Twelve patients with stage ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ijrobp.2013.12.034

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Funding agency for:
Warren, S
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Funding agency for:
Fenwick, JD
Publisher:
Elsevier Publisher's website
Journal:
International journal of radiation oncology, biology, physics Journal website
Volume:
88
Issue:
5
Pages:
1148-1153
Publication date:
2014-04-05
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
URN:
uuid:0c59d069-3f80-408f-9a8c-2d37a10d1140
Source identifiers:
449237
Local pid:
pubs:449237

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