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A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23.

Abstract:

Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome-wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddr479

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Journal:
Human molecular genetics More from this journal
Volume:
21
Issue:
2
Pages:
456-462
Publication date:
2012-01-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Language:
English
Keywords:
Pubs id:
pubs:245979
UUID:
uuid:0c5941e3-c2e0-437d-844d-029078069373
Local pid:
pubs:245979
Source identifiers:
245979
Deposit date:
2012-12-19

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