Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue.

Journal article

Giant-cell tumor of bone (GCTB) and giant-cell tumor of soft tissue (GCTST) are tumors that contain a prominent osteoclastlike giant-cell component. The precise relationship between these morphologically similar tumors is unclear, and the cellular mechanism whereby giant cells accumulate within these and other locally aggressive tumors is uncertain. In this study, we have examined the cytochemical, functional, and molecular phenotype of the mononuclear and multinucleated components of GCTB an...

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Authors: Lau, Y; Sabokbar, A; Gibbons, C; Giele, H; Athanasou, N

• Publication status: Published
• Journal: Human pathology
• Volume: 36
• Issue: 9
• Pages: 945-954
• Publication date: 2005-09-01
• DOI: 10.1016/j.humpath.2005.07.005
• EISSN: 1532-8392
• ISSN: 0046-8177
• Language: English
• Keywords: Immunohistochemistry; Membrane Glycoproteins; Receptors, Cytoplasmic and Nuclear; Coculture Techniques; RANK Ligand; Giant Cell Tumor of Bone; TNF-Related Apoptosis-Inducing Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Tumor Necrosis Factor; Osteoprotegerin; Glycoproteins; Monocytes; Soft Tissue Neoplasms; Phenotype; Osteoclasts; Giant Cell Tumors; Apoptosis Regulatory Proteins; Osteolysis; Bone Neoplasms; Bone Resorption; Carrier Proteins; Stromal Cells; RNA, Messenger; Humans; Tumor Necrosis Factor-alpha