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Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue.

Abstract:

Giant-cell tumor of bone (GCTB) and giant-cell tumor of soft tissue (GCTST) are tumors that contain a prominent osteoclastlike giant-cell component. The precise relationship between these morphologically similar tumors is unclear, and the cellular mechanism whereby giant cells accumulate within these and other locally aggressive tumors is uncertain. In this study, we have examined the cytochemical, functional, and molecular phenotype of the mononuclear and multinucleated components of GCTB an...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Human pathology More from this journal
Volume:
36
Issue:
9
Pages:
945-954
Publication date:
2005-09-01
DOI:
EISSN:
1532-8392
ISSN:
0046-8177

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