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Journal article

Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria.

Abstract:

The relationships between the pharmacokinetic properties of quinine during a 7-day treatment course and the therapeutic response were studied in 30 adult patients with uncomplicated falciparum malaria monitored for > or = 28 days. All patients received a 7-day oral quinine regimen either alone (n = 22) or in combination with rifampin (n = 8). The median fever clearance time was 58.5 h, and the mean +/- standard deviation parasite clearance time was 73 +/- 24 h. After recovery, six patients...

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Publication status:
Published

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Journal:
Antimicrobial agents and chemotherapy
Volume:
47
Issue:
11
Pages:
3458-3463
Publication date:
2003-11-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:0c5036a2-7409-4a9d-9c1d-5aa264c5a023
Source identifiers:
38813
Local pid:
pubs:38813

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