- Abstract:
-
The relationships between the pharmacokinetic properties of quinine during a 7-day treatment course and the therapeutic response were studied in 30 adult patients with uncomplicated falciparum malaria monitored for > or = 28 days. All patients received a 7-day oral quinine regimen either alone (n = 22) or in combination with rifampin (n = 8). The median fever clearance time was 58.5 h, and the mean +/- standard deviation parasite clearance time was 73 +/- 24 h. After recovery, six patients...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/aac.47.11.3458-3463.2003
-
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- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 47
- Issue:
- 11
- Pages:
- 3458-3463
- Publication date:
- 2003-11-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:0c5036a2-7409-4a9d-9c1d-5aa264c5a023
- Source identifiers:
-
38813
- Local pid:
- pubs:38813
- Copyright date:
- 2003
Journal article
Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria.
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