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Journal article

Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein

Abstract:

The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that shield it from immune surveillance. The high density of glycans on the trimer surface imposes steric constraints limiting the actions of glycan processing enzymes, such that multiple under-processed structures remain on specific areas. These oligomannose glycans are recognized by broadly neutralizing antibodies (bNAbs) that are not thwarted by the glycan shield but, paradoxically, target it. Our site-specif...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2016.02.058

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Corpus Christi College, Oxford
Funding agency for:
Behrens, A
Grant:
Chris Scanlan Memorial Scholarship
More from this funder
Name:
Medical Research Council
Grant:
MR/K024426/1
More from this funder
Name:
International AIDS Vaccine Initiative
Grant:
International AIDS Vaccine Initiative
More from this funder
Name:
National Institutes of Health
Grant:
AI110657 (HIVRAD); R37 AI36082
More from this funder
Name:
Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery
Grant:
CHAVI-ID 1UM1AI100663
Publisher:
Cell Press
Journal:
Cell Reports More from this journal
Volume:
14
Issue:
11
Pages:
2695-2706
Publication date:
2016-03-22
Acceptance date:
2016-02-10
DOI:
ISSN:
2211-1247
Pubs id:
pubs:607239
UUID:
uuid:0c5027cf-0add-4a9f-b6c9-579618d6963f
Local pid:
pubs:607239
Source identifiers:
607239
Deposit date:
2016-03-02

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