- Abstract:
- The in vitro production, assay and partial characterization of an extremely potent antigen-specific T helper cell factor to poly-L-(Tyr, Glu)-poly-DL-Ala--poly-L-Lys [(T,G)-A--L] which may be an important physiological mediator of T cell function in vivo is described. The factor has an antigen-binding site, Ia and Ig-like determinants on the same molecular complex. The response to (T, G)-A--L is under H-2-linked Ir gene control, some but not all low responder haplotypes will produce the factor.
- Publication status:
- Published
- Publisher copy:
- 10.1002/eji.1830070703
-
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- Journal:
- European journal of immunology
- Volume:
- 7
- Issue:
- 7
- Pages:
- 417-421
- Publication date:
- 1977-07-05
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- URN:
-
uuid:0c4b1091-551e-45a0-837a-3ba68c69e653
- Source identifiers:
-
481872
- Local pid:
- pubs:481872
- Copyright date:
- 1977
Journal article
In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.
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