In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.

Journal article

The in vitro production, assay and partial characterization of an extremely potent antigen-specific T helper cell factor to poly-L-(Tyr, Glu)-poly-DL-Ala--poly-L-Lys [(T,G)-A--L] which may be an important physiological mediator of T cell function in vivo is described. The factor has an antigen-binding site, Ia and Ig-like determinants on the same molecular complex. The response to (T, G)-A--L is under H-2-linked Ir gene control, some but not all low responder haplotypes will produce the factor.

Authors: Howie, S; Feldman, M

• Publication status: Published
• Journal: European journal of immunology
• Volume: 7
• Issue: 7
• Pages: 417-421
• Publication date: 1977-07-01
• DOI: 10.1002/eji.1830070703
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: T-Lymphocytes; Dose-Response Relationship, Immunologic; Mice; Cross Reactions; Peptides; Mice, Inbred CBA; Genetic Linkage; Spleen; Immunosorbents; Haploidy; Mice, Inbred C57BL; Epitopes; Binding Sites, Antibody; Animals; Dinitrobenzenes; Histocompatibility Antigens