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The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages.

Abstract:

BACKGROUND: Trypanosomatids utilise polycistronic transcription for production of the vast majority of protein-coding mRNAs, which operates in the absence of gene-specific promoters. Resolution of nascent transcripts by polyadenylation and trans-splicing, together with specific rates of mRNA turnover, serve to generate steady state transcript levels that can differ in abundance across several orders of magnitude and can be developmentally regulated. We used a targeted oligonucleotide microar...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1471-2164-9-298

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC genomics Journal website
Volume:
9
Issue:
1
Pages:
Article no. 298
Publication date:
2008-01-01
DOI:
EISSN:
1471-2164
ISSN:
1471-2164
URN:
uuid:0c4ae554-a90e-4614-b7dc-df0b02ea0d65
Source identifiers:
56335
Local pid:
pubs:56335

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