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Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes.

Abstract:

During female meiosis, bivalent chromosomes are thought to be held together from birth until ovulation by sister chromatid cohesion mediated by cohesin complexes whose ring structure depends on kleisin subunits, either Rec8 or Scc1. Because cohesion is established at DNA replication in the embryo, its maintenance for such a long time may require cohesin turnover. To address whether Rec8- or Scc1-containing cohesin holds bivalents together and whether it turns over, we created mice whose kleis...

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Publication status:
Published

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Publisher copy:
10.1101/gad.605910

Authors


Tachibana-Konwalski, K More by this author
van der Weyden, L More by this author
Champion, L More by this author
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Journal:
Genes and development
Volume:
24
Issue:
22
Pages:
2505-2516
Publication date:
2010-11-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:0c49efd4-2687-44c8-b741-683405558e0d
Source identifiers:
98385
Local pid:
pubs:98385

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